Chemical chain termination resolves the timing of ketoreduction in a partially reducing iterative type I polyketide synthase.
نویسندگان
چکیده
Synthetic chain terminators were used to capture the biosynthetic intermediates from a partially reducing iterative type I polyketide synthase, which is integrated into a multimodular biosynthesis enzyme. The off-loaded metabolites clarified the timing of ketoreduction and aromatization in the assembly of the antibiotic micacocidin.
منابع مشابه
Title Insights into the Programmed Ketoreduction of Partially Reducing Polyketide Synthases : Stereo-and Substrate- Specificity of the Ketoreductase Domain Insights into the Programmed Ketoreduction of Partially Reducing Polyketide Synthases: Stereo-and Substrate-specificity of the Ketoreductase Domain
2014). Insights into the programmed ketoreduction of partially reducing polyketide synthases : stereo-and substrate-specificity of the ketoreductase domain. One of the hallmarks of iterative polyketide synthases (PKS) is the programming mechanism which is essential for the generation of structurally diverse polyketide products. In partially reducing iterative PKSs (PR-PKS), the programming mech...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 47 شماره
صفحات -
تاریخ انتشار 2015